Founded in 1599 as a small sacred building, the Church of the SS Annunziata underwent its architectural development in 1713. This occurred when the Municipality finally fulfilled a vow made nearly a century earlier, in 1631, to erect a marble altar and a tribune to the Virgin Mary should the plague (the 'Manzonian' plague) come to an end.

The crowned Dolphin, emblem of the City, towers above the altar; below it lies a grand canvas painted by Carlo Sacconi, depicting the people kneeling as they invoke the grace of the Virgin Mary. Also of note is a painting by Baldassarre Franceschini, known as 'Il Volterrano,' showing Saint Charles Borromeo administering the Eucharist to plague victims. The church is currently closed.